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Rotarix vaccine dose

Rotavirus Vaccine Dosage Guide with Precautions - Drugs

Rotarix(R): 1 mL, orally, for 2 doses, administered at least 4 weeks apart RotaTeq(R): 2 mL (1 dosing tube), orally, for 3 doses, administered 4 to 10 weeks apart Comments:-Administer beginning at 6 weeks of age; the 2 dose series/Rotarix(R) should be completed by 24 weeks of age; the 3 dose series/RotaTeq(R) should be completed by 32 weeks Each 1-mL dose is administered orally with a prefilled applicator 1 Administer first dose to infants beginning at 6 weeks of age 1 There should be an interval of at least 4 weeks between the first and second dose 1 The 2-dose series should be completed by 24 weeks of age

RotaTeq® is given in three doses at ages 2 months, 4 months, and 6 months Rotarix® is given in two doses at ages 2 months and 4 months The first dose of either vaccine should be given before a child is 15 weeks of age. Children should receive all doses of rotavirus vaccine before they turn 8 months old Two rotavirus vaccines are currently licensed for infants in the United States: RotaTeq® (RV5) is given in 3 doses at ages 2 months, 4 months, and 6 months Rotarix® (RV1) is given in 2 doses at ages 2 months and 4 months The first dose of either vaccine should be given before a child is 15 weeks of age out or regurgitates most of the vaccine dose, a single replacement dose may be given at the same vaccination visit. It is recommended that infants who receive a first dose of Rotarix complete the 2-dose regimen with Rotarix . There are no data on safety, immunogenicity or efficacy when Rotarix is administere Two rotavirus vaccines are licensed. Both are live, attenuated vaccines. RV5 (RotaTeq®) RV1 (ROTARIX®) Number of doses in series 3 2 Recommended ages for doses 2, 4, and 6 months 2 and 4 months Minimum age for first dose 6 weeks 14 weeks, 6 day

Dosing and Administration - GSKpr

ROTAVIRUS VACCINE | PSM Made Easy

Rotavirus Vaccines CD

  1. 8 consecutive days following vaccination with ROTARIX (i.e. day of vaccination and the next 7 days). A diary card was completed to record irritability, cough/runny nose, the infant's temperature, loss of appetite, vomiting, or diarrhea on a daily basis during the first week following each dose of ROTARIX or placebo. Adverse reactions amon
  2. istration. Age limit for 1st dose. Age limit for 2nd dose. Age limit for 3rd dose. Minimum interval between doses. Rotarix (GlaxoSmithKline Australia) 2 oral doses (1.5 mL/dose) 2 and 4 months. 6-14 weeks (before turning 15 weeks of age) 10-24 weeks (before turning 25 weeks of age) Not applicable. 4 week
  3. istered in two doses. The applicant has provided the following results for definite IS diagnosed within 31 days (Day 0 to Day 30) after any dose. There..
  4. RotaTeq is a live, reassortant, pentavalent human-bovine rotavirus vaccine containing 5 rotavirus reassortants: G1, G2, G3, G4 and P[8] derived from human and bovine viral species.22 Rotarix is a live, monovalent, human attenuated rotavirus vaccine derived from the most common human rotavirus strain G1P[8].2

Rotarix is given as two doses, at least four weeks apart. The first dose is given when the baby is older than six weeks. Ideally, both doses should be given before the baby is aged 16 weeks and they must be given by the time the baby is 24 weeks old Do not report 90460, 90471-90474 for the administration of COVID vaccines. ^ Counseling must be done by a qualified healthcare professional such as a physician, nurse practitioner, or physician assistant Rotarix (human monovalent rotavirus vaccine) The vaccination course of Rotarix is 2 doses, at 2 and 4 months of age: Give the 1st dose between 6 and 14 weeks of age — that is, before turning 15 weeks old

ROTARIX is available as a vial of lyophilized vaccine to be reconstituted with a liquid diluent in a prefilled oral applicator. Each 1-mL dose contains a suspension of at least 106.0 median Cell... 4 CONTRAINDICATIONS 4.1 Hypersensitivity - A demonstrated history of hypersensitivity to any component of the vaccine We examined fecal shedding of pentavalent rotavirus vaccine (RV5) for 9 days following the first dose of vaccine in infants between 6 and 12 weeks of age. Rotavirus antigen was detected by enzyme immunoassay (EIA), and vaccine-type rotavirus was identified by nucleotide sequencing based on genetic relatedness to the RV5 VP6 gene Rotarix® vaccine will help to protect your baby against gastroenteritis caused by rotavirus infection. This is the most common virus causing sickness and diarrhoea in young children. Your baby will be given two doses - usually at their scheduled two- and three-month visits. The most common side-effects are mild diarrhoea and irritability The maximum age recommended for the last dose of RotaTeq is 32 weeks; it is 24 weeks and 6 days for Rotarix. In the United States, where RotaTeq has been generally administered at ages corresponding to those studied in the pivotal trials, post-licensure safety data do not suggest an increased risk of intussusception

Rotavirus Vaccination CD

2 ROTARIX is administered for the first dose and another rotavirus vaccine is administered for the second dose or vice versa. Paediatric population ROTARIX should not be used in children over 24 weeks of age. Method of administration ROTARIX is for oral use only. ROTARIX SHOULD UNDER NO CIRCUMSTANCES BE INJECTED. For instructions for the preparation or reconstitution of the medicinal product. The American Academy of Pediatrics (AAP)'s updated guidelines on the use of rotavirus vaccine for prevention of rotavirus disease (2009) stated that in April 2008, a live, oral, human attenuated rotavirus vaccine (RV1 [Rotarix]) was licensed as a 2-dose series for use in infants in the United States The first dose of Rotarix is always given before 15 weeks of age, as the side effect of intussusception seems unlikely to occur if the vaccine doses start at this age. This also reduces the chance of the vaccine being wrongly blamed for cases of intussusception that peak naturally at around 5 months of age Objective: The purpose of this double-blind, randomised, placebo-controlled, adaptive design trial with frequent interim analyses is to determine if Australian Indigenous children, who receive an additional (third) dose of human rotavirus vaccine (Rotarix, GlaxoSmithKline) for children aged 6 to < 12 months, would improve protection against clinically significant all-cause gastroenteritis

333 Rotavirus Rotavirus August 2015 Green ook Chapter 27b v3_0 Dosage and schedule Schedule for Rotarix® First dose of 1.5 ml of Rotarix® vaccine at two months (approximately eight weeks) of age. Second dose of 1.5 ml at least four weeks after the first dose. It is preferable that the full course of two doses of Rotarix® be completed before 16 weeks of age, allowing at least four weeks. To reduce the risk of this happening, the first dose of the vaccine should not be given to babies older than 15 weeks of age. Which babies should have the rotavirus vaccine? The rotavirus oral vaccine is a routine childhood vaccination for babies aged 8 weeks and 12 weeks dose and another rotavirus vaccine were administered for the second dose or vice versa. In the event that the infant spits out or regurgitates most of the vaccine dose, a singl

of rotavirus vaccine? Yes. A routine pre-immunization health assessment should be conducted including questions screening for contraindications specific to rotavirus vaccine, such as: A severe allergic reaction to a previous dose of rotavirus vaccine or any contents of the vaccine or its container. A history of intussusception in Just 2 Doses ROTARIX is a vaccine indicated for the prevention of rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9) when administered as a 2-dose series. ROTARIX is approved for use in infants 6 weeks to 24 weeks of age RotaTeq ® (RV5) is given orally in 3 doses, one dose at age 2 months, 4 months, and 6 months. Rotarix ® (RV1) is given orally in 2 doses, one dose at age 2 months and 4 months. If any dose in the series is either RotaTeq ® or unknown, default to a 3-dose series

Rotavirus vaccine is administered by putting drops in the child's mouth. Babies should get 2 or 3 doses of rotavirus vaccine, depending on the brand of vaccine used. The first dose must be administered before 15 weeks of age. The last dose must be administered by 8 months of age Rotavirus (RV) Rotarix: 1.0 mL Oral Rotateq: 2.0 mL Varicella (Var) 0.5 mL SC Zoster (Zos) 0.65 mL SC Combination Vaccines DTaP-HepB-IPV (Pediarix) DTaP-IPV/Hib (Pentacel) DTaP-IPV (Kinrix) Hib-HepB (Comvax) 0.5 mL IM MMRV (ProQuad) <12 yrs: 0.5 mL SC HepA-HepB (Twinrix) >18 yrs: 1.0 mL IM Administering Vaccines: Dose, Route, Site, and Needle Siz

The Pentavalent Live Vaccine (RV5) has a different rotavirus vaccine dose system. Unlike RVI vaccine RV5 vaccine requires three doses. The first rotavirus vaccine dose is administered at 2 months, then second dose at 4 months and the third at 6 months. Each rotavirus vaccine injection is administered at a gap of 4 to 8 weeks It is an oral vaccine, not an injection. A few drops of liquid (1.5ml) are given from a dropper into the mouth. Babies receive two doses, at 8 weeks and 12 weeks, alongside the other routine vaccines given at these times (see the UK vaccination schedule)

Ask the Experts: Rotavirus Vaccine

If RV1 is used, it should be given orally in a two-dose series at two and four months of age. Rotavirus vaccine may be administered to infants with minor acute illness. Regardless of which vaccine.. ROTARIX VACCINE, ORAL SUSP 10E6/ML 1ML (10/PK RV1 is a 2-dose vaccine recommended at 2 and 4 months of age, and RV5 is a 3-dose vaccine recommended at 2, 4, and 6 months of age

Recommended number of doses. Two or three doses before the age of 8 months, depending on the type of vaccine. Note: Unlike most vaccines, the rotavirus vaccine is given by mouth rather than as an injection. Recommended ages. At 2 months; At 4 months; At 6 months (not needed if the Rotarix brand of vaccine was given at 2 and 4 months Your child must get the first dose of rotavirus vaccine before 15 weeks of age, and the last by age 8 months. Rotavirus vaccine may safely be given at the same time as other vaccines. Almost all babies who get rotavirus vaccine will be protected from severe rotavirus diarrhea. And most of these babies will not get rotavirus diarrhea at all Rotarix® Rotavirus Vaccine Infants 6 to 24 Weeks of Age 10E6 / mL Suspension Prefilled Oral Applicator 1 mL Administer first dose to infants beginning at 6 weeks of age Administer second dose after an interval of at least 4 weeks and prior Vial of lyophilized vaccine to be reconstituted with accompanying liqu out or regurgitates most of the vaccine dose, a single replacement dose may be given at the same vaccination visit. It is recommended that infants who receive a first dose of Rotarix complete the 2-dose regimen with Rotarix. There are no data on safety, immunogenicity or efficacy when Rotarix is administered for th

Rotavirus vaccine - Wikipedi

At $20 per dose, the program would cost $289 million and realize a net loss of $107 million to the health care system-$103 per case prevented. The program would provide a net savings of $296 million to society. Threshold analysis identified a break-even price per dose of $9 for the health care system and $51 for the societal perspective About 75% of U.S. doctors prescribe the three-dose RotaTeq vaccine, made by Merck, which was approved in 2006. Because rotavirus causes severe diarrheal disease in infants, rotavirus vaccination..

Rot-1 vaccine (Rotarix ®) requires 2 doses (at least 4 weeks apart) and Rot-5 vaccine (RotaTeq ®) requires 3 doses (4 to 10 weeks apart). Rotavirus vaccines can be given with other routine vaccines at 2 and 4 months of age, or 2, 4 and 6 months of age Why are several doses of some vaccines needed? The number of necessary doses of a particular vaccine depends on many factors including the type of vaccine, the burden of disease in the community, and how the immune system works: Type of vaccine . Vaccines made from live, weakened viruses work by reproducing at low levels in the body

The Rotarix brand of rotavirus oral vaccine is given in a series of 2 doses. The first dose is usually given when the child is 6 weeks old. The second dose is then given at least 4 weeks after the first dose, but before the child reaches 24 weeks of age an infant spits out or regurgitates most of the vaccine dose, a single replacement dose may be given at the same vaccination visit. It is strongly recommended that infants who receive a first dose of ROTARIX complete the 2-dose regimen with ROTARIX. Administration . ROTARIX is for ORAL use only. ROTARIX SHOULD UNDER NO CIRCUMSTANCES BE INJECTED The third nationally licensed rotavirus vaccine is the Lanzhou lamb rotavirus (LLR) vaccine developed by Lanzhou Institute of Biological Products in China. This vaccine was licensed in 2000 and has been available on the Chinese private market with an estimated 60 million doses provided

Rotavirus vaccine. Rotavirus vaccine is administered by putting drops in the child's mouth. Babies should get 2 or 3 doses of rotavirus vaccine, depending on the brand of vaccine used. The first dose must be administered before 15 weeks of age. The last dose must be administered by 8 months of age The researchers studied a cohort of 1,393 children aged 6 to 14 weeks, at multiple centers between 2011 and 2013. The two FDA-approved, commercially licensed rotavirus vaccines — RotaTeq (RV5. Rotarix is indicated for the prevention of rotavirus gastroenteritis caused by G1 and non-G1 types (G3, G4, and G9) when administered as a 2-dose series in infants and children. It was approved in Europe in 2006 and by the U.S. FDA in April 2008. It is administered by mouth The RotaTeq brand of rotavirus oral vaccine is given in a series of 3 doses. The first dose is usually given when the child is 6 to 12 weeks old. The booster doses are then given at 4-week to 10-week intervals before the child reaches 32 weeks of age. The Rotarix brand of rotavirus oral vaccine is given in a series of 2 doses

Find everything you need to know about Rotateq (Rotavirus Vaccine, Live (Oral)), including what it is used for, warnings, reviews, side effects, and interactions. Learn more about Rotateq. The first dose was given between 6 and 12 weeks of age and the second dose was administered 4 to 8 weeks later. After two doses of Rotarix, the protective vaccine efficacy against severe rotavirus gastroenteritis requiring hospitalisation and/or rehydration therapy in a medical facility was 84.7% (95% CI: 71.7; 92.4) The Rotavirus Vaccine (Rotarix®) is part of the Immunisation schedule. For the vaccine to be effective the first dose must be given before 14 weeks of age and the second dose course completed by 24 weeks of age. There will be some infants in NICU who will need to have their first dose before or at discharge. Rotarix® is a live ORAL vaccine

Rota virus

Table. Upper age limits for dosing of oral rotavirus vaccine

AIM: This study was undertaken to compare the immunogenicity of a three dose and five dose schedule of an oral live-attenuated human rotavirus vaccine, Rotarix in south Indian infants. METHOD: Healthy infants (N=90), six to seven weeks of age were enrolled to receive three doses (n=45) or five doses of Rotarix vaccine (n=45) along with other. The Centers for Disease Control and Prevention (CDC) approved a rotavirus vaccine for use in all infants in the United States in 2006. The vaccine, called RotaTeq ®, is given as a series of three doses by mouth at 2 months, 4 months and 6 months of age and can be given with other vaccines typically administered at those times.A second vaccine, called Rotarix ®, was approved for use in June.

Statistical Review and Evaluation - Rotarix FD

  1. Rotavirus vaccine (Rotarix) Newborn Use Only 2018 NMF Consensus Group Rotavirus vaccine Page 1 of 4 This is a printed copy. Refer to Neomed electronic system for the most up to date version Alert ORAL ADMINISTRATION ONLY The first dose of rotavirus vaccine should be given to infants between 6 and 14 week
  2. Since they began in 2007, rotavirus vaccinations have prevented more than 7,000 hospital admissions every year. All babies can receive free immunisation against rotavirus with two doses of an oral vaccine. The first dose of rotavirus vaccine must be given by 14 weeks and six days of age. Serious reactions to the rotavirus vaccine are rare
  3. Rotavirus Vaccination Programme: Information for healthcare professionals 7 Rotavirus vaccination schedule All children should be offered vaccine to protect against rotavirus with their primary vaccines scheduled at 8 weeks and 12 weeks of age. Children should receive 2 doses of Rotarix vaccine, with an interval of at least 4 weeks between doses
  4. Rotavirus vaccine protects young children against the rotavirus infections, which are a leading cause of severe diarrhea. The table shows the awarded price per dose (in US$) per product per supplier per calendar year, based on a multi year supply agreement
  5. Vaccine trials have been published in which live rotavirus vaccine strains were fed to healthy human infants (Pichichero et al. 1990, Vesikari et al. 1985). However, their ID 50 estimates were several orders of magnitude higher than that observed by Ward et al. (1986), probably because the virus strains were attenuated
  6. Compare prices and print coupons for Rotarix (Rotavirus Vaccine) and other Rotavirus drugs at CVS, Walgreens, and other pharmacies. Prices start at $133.2
ROTARIX (Rotavirus Vaccine, Live, Oral) Oral Suspension

In Brazil, no increased risk of intussusception was found after the administration of the first dose of Rotarix vaccine, a situation in which the rotavirus vaccine was coadministered with oral. In your description, mention the brand, dose, and period of time that you used the drug or treatment. My baby got the rotavirus vaccine rotateq at 7 weeks old and had vomiting and diarrhoea.

Rotavirus vaccines (Rotarix and RotaTeq) for prevention of

  1. The use of a three-dose, monovalent oral rotavirus vaccine — Rotavac (Bharat Biotech International) — was not associated with an increased risk for intussusception during a 3-year trial in India
  2. The estimated risk associated with dose 1 of RV5 was about 1.5 excess cases per 100,000 recipients of the first dose of the vaccine, which was roughly one tenth the risk associated with the first.
  3. The new rotavirus vaccine is called Rotarix, from GlaxoSmithKline. Like RotaTeq , Merck's existing vaccine, it protects against the leading cause of severe diarrhea in children
  4. istered using an oral applicator
  5. Serum's rotavirus vaccine shows significant efficacy, gets govt order for 3.8 mn doses The study showed the vaccine to be safe, well tolerated, and to provide significant efficacy againstn.
Rotavirus: The Disease and The Vaccine - HSE

Rotavirus vaccine effectiveness was highest in preventing the most severe cases of rotavirus gastroenteritis, and even 1 dose of rotavirus vaccine appeared to be associated with less severe outcomes. Unvaccinated rotavirus cases were classified as having severe infections 4 times more often than vaccinated rotavirus cases Rotavirus Vaccine Available Brands. Filter by: Clear. Brand Name Dosage Form Strength Company Rotarix Oral Suspension 1.5 ml/dose GlaxoSmithKline 1 pre-filled oral applicator: ৳ 1,474.00. Vaccine effectiveness against rotavirus hospitalization and emergency room visits was 69% (95% CI: 71-100%) following 1 dose, 81% (95% CI: 13-96%) following 2 doses and 88% (95% CI: 68-96%) following 3 doses using a case control design comparing children with lab-confirmed rotavirus gastroenteritis to a group of controls with either rotavirus.

Results. We first estimated reductions in rotavirus hospitalization rates assuming that 75% of infants received the first dose of rotavirus vaccine at 6 weeks of age instead of 8 weeks, and a baseline rate of 52 rotavirus hospitalizations per 10,000 infants <3 months of age before introduction of currently licensed rotavirus vaccines in the United States (Table) ROTARIX is an oral live-attenuated human rotavirus vaccine licensed in more than 100 countries around the world. More than 25 million doses of ROTARIX have been distributed worldwide

Menactra packagingRotavirus vaccine presentation Rotateq 28 june 2013

Depending on the specific type of vaccine, dosing schedules for the rotavirus vaccine can vary. The standard dosage for Rotarix is two doses given by mouth at least four weeks apart. For RotaTeq, the standard dosage is three doses given 4 to 10 weeks apart. These dosing schedules usually coincide nicely with standard well-baby visits Rotarix ® (RV1) is given orally in 2 doses, one dose at age 2 months and 4 months. If any dose in the series is either RotaTeq ® or unknown, default to a 3-dose series. If the first dose of rotavirus vaccine is inadvertently given at age ≥ 15 weeks, the remaining doses should be given at the routinely recommended intervals Rotarix® Rotavirus Vaccine Infants 6 to 24 Weeks of Age 10E6 / mL Suspension Prefilled Oral Applicator 1 mL Administer first dose to infants beginning at 6 weeks of age Administer second dose after an interval of at least 4 weeks and prior Vial of lyophilized vaccine to be reconstituted with accompanying liqu oral rotavirus vaccine (Rotarix) dose should be given by 15 weeks however if a child presents later than 15 weeks of age the child can still receive the 1st dose of the rotavirus vaccine up to the age of 7 months and 0 days and receive the second dose before 8 months and 0 days or second dose of rotavirus vaccine, has been reported in some countries. Most of this risk is following the first dose and within 7 days of dose receipt. This is considerably lower than the background rate of intussusception of 25 in 100,000 BC infants

Rotarix®, a two-dose rotavirus vaccine into her Expanded Program on Immunization (EPI). The vaccine is admin-istered orally at 6 and 10 weeks of age [6]. Over the first 20 years of its introduction in Kenya, the rotavirus vaccine is predicted to avert 60,935 undiscounted deaths and 216,454 hospital admissions among children age The study will evaluate safety and immunogenicity of LORV (Rotarix and RV3-BB) when TV P2-VP8, a parentally administered rotavirus vaccine is administered either concomitantly or as a prime/boost model. Participants would be newborn babies or infants approximately at 6 weeks of age ta the time of enrollment The rotavirus vaccine is available free as part of the National Immunisation Program and is offered to children at 6 weeks of age and 4 months of age. Australian children are given the brand Rotarix ® , which requires all children to have two doses • Each dose should be separated by at least 4 weeks, and given at the same time as other normal childhood vaccinations. • Maximum age of the first dose of rotavirus vaccination is 14 weeks and 6 days, and maximum age for any dose is 8 months [4, 5] The rotavirus vaccine used in the United States in the late 1990s increased the intussusception risk by 1 to 2 cases per 10,000 vaccination recipients. Tens of millions of doses of the current rotavirus vaccines have already been administered globally

the two-dose RotarixTM schedule at 2 and 4 months of age. Rotarix™ (GSK) and RotaTeq® (Merck) are equivalent vaccines in terms of clinical safety and efficacy; the primary difference is in the dosing schedule (i.e., two versus three doses). The first dose of rotavirus vaccine (Rotarix™ or RotaTeq®) should be given no earlier than 6 week Rotavirus Vaccine Dosage General Dosage Information. Some considerations for children receiving the rotavirus vaccine include the following: This is one of the few vaccines that are given by mouth (not as an injection). If your child spits out some or all of the vaccine, a replacement dose may be. The rotavirus vaccine is recommended for children younger than 32 weeks of age. Children should get 3 doses, at least 4 weeks apart. Vaccination usually starts at around 2 months of age, with another dose at around 4 months and 6 months of age. How Well It Work The maximum age for dose 1 of rotavirus vaccine is 14 weeks and 6 days of age (previously, the recommendation was 12 weeks). The maximum age for the last dose of rotavirus vaccine is 8 months and 0 days (previously, the recommendation was 32 weeks)

vaccine/toxoid) (List separately in addition to code for primary procedure) 90680 Rotavirus vaccine, pentavalent (RV5), 3 dose schedule, live, for oral use 90681 Rotavirus vaccine, human, attenuated (RV1), 2 dose schedule, live, for oral use . Note: CPT codes, descriptions and materials are copyrighted by the American Medical Association (AMA) In this double-blind trial, two oral doses of a live attenuated G1P rotavirus vaccine were highly efficacious in protecting infants against severe diarrheal disease. In this double-blind trial, two.. The Rotarix brand of rotavirus oral vaccine is given in a series of 2 doses. The first dose is usually given when the child is 6 weeks old. The second dose is then given at least 4 weeks after the first dose, but before the child reaches 24 weeks of age. Your child's booster schedule may be different from these guidelines The rotavirus vaccine, called RotaTeq, protects your child against a bug called rotavirus, which causes a nasty stomach flu. This strain of virus may make children sicker than others that cause.

Rotarix - FDA prescribing information, side effects and usesHK Child Vaccination Plan | Adult & Travel VaccinesNDC 58160-854 Rotarix Rotavirus Vaccine, Live, Oral

Rotarix is an oral vaccine against rotavirus infection. It contains a live, weakened form of human rotavirus. Rotavirus infection is the most common cause of severe diarrhoea in young children and. A primary series of Rotarix is two doses at 2 and 4 months of age for a total of 2 doses. 3) Unknown type of rotavirus vaccine given at 2 or 4 months or a mixed schedule (one dose of each type was used): If you do not know what type of rotavirus vaccine the child received at 2 or 4 months of age o Rotateq is a pentavalent (prepared from 5 strains) vaccine given in 3 doses at age 2, 4, and 6 months. Rotarix is monovalent (prepared from 1 strain) and is given in 2 doses at age 2 and 4 months. Either is recommended, but about 10 times more doses of the pentavalent vaccine have been administered Vaccine trials have been published in which live rotavirus vaccine strains were fed to healthy human infants (Pichichero et al. 1990, Vesikari et al. 1985). However, their ID 50 estimates were several orders of magnitude higher than that observed by Ward et al. (1986), probably because the virus strains were attenuated

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